Evo–devo: extending the evolutionary synthesis

GB Müller - Nature reviews genetics, 2007 - nature.com
Evolutionary developmental biology (evo–devo) explores the mechanistic relationships
between the processes of individual development and phenotypic change during evolution …

Optical projection tomography

J Sharpe - Annu. Rev. Biomed. Eng., 2004 - annualreviews.org
▪ Abstract Optical projection tomography is a new approach for three-dimensional (3-D)
imaging of small biological specimens. It fills an imaging gap between MRI and confocal …

3D reconstruction of histological sections: Application to mammary gland tissue

I Arganda‐Carreras… - Microscopy research …, 2010 - Wiley Online Library
In this article, we present a novel method for the automatic 3D reconstruction of thick tissue
blocks from 2D histological sections. The algorithm completes a high‐content (multiscale …

Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain

HU Dodt, U Leischner, A Schierloh, N Jährling… - Nature …, 2007 - nature.com
Visualizing entire neuronal networks for analysis in the intact brain has been impossible up
to now. Techniques like computer tomography or magnetic resonance imaging (MRI) do not …

Optical projection tomography as a tool for 3D microscopy and gene expression studies

J Sharpe, U Ahlgren, P Perry, B Hill, A Ross… - Science, 2002 - science.org
Current techniques for three-dimensional (3D) optical microscopy (deconvolution, confocal
microscopy, and optical coherence tomography) generate 3D data by “optically sectioning” …

A gene network model accounting for development and evolution of mammalian teeth

I Salazar-Ciudad, J Jernvall - Proceedings of the National …, 2002 - National Acad Sciences
Generation of morphological diversity remains a challenge for evolutionary biologists
because it is unclear how an ultimately finite number of genes involved in initial pattern …

The innovation triad: an EvoDevo agenda

GB Müller, SA Newman - Journal of Experimental Zoology Part …, 2005 - Wiley Online Library
This article introduces a special issue on evolutionary innovation and morphological novelty,
two interrelated themes that have received a remarkable increase of attention over the past …

High-resolution episcopic microscopy: a rapid technique for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology

WJ Weninger, SH Geyer, TJ Mohun… - Anatomy and …, 2006 - Springer
We describe a new methodology for rapid 2D and 3D computer analysis and visualisation of
gene expression and gene product pattern in the context of anatomy and tissue architecture …

Phenotyping transgenic embryos: a rapid 3-D screening method based on episcopic fluorescence image capturing

WJ Weninger, T Mohun - Nature genetics, 2002 - nature.com
We describe a technique suitable for routine three-dimensional (3-D) analysis of mouse
embryos that is based on episcopic fluorescence images captured during serial sectioning …

Divergent regulation of dihydrofolate reductase between malaria parasite and human host

K Zhang, PK Rathod - Science, 2002 - science.org
For half a century, successful antifolate therapy against Plasmodium falciparum malaria has
been attributed to host-parasite differences in drug binding to dihydrofolate reductase …