▪ Abstract Plasma membrane Na+-Ca2+ exchange is an essential component of Ca2+
signaling pathways in several tissues. Activity is especially high in the heart where the …

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Background Micro RNA s (mi RNA s) play a key role in the development of heart failure, and
recent studies have shown that the muscle‐specific miR‐1 is a key regulator of cardiac …

Background—Spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) can
generate afterdepolarizations, and these have the potential to initiate arrhythmias …

Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

Objective: Although it is generally accepted that endurance training improves cardiac
function after myocardial infarction the sub-cellular mechanisms are uncertain. The present …

Sodium–calcium exchange (NCX) is the major calcium (Ca) efflux mechanism of ventricular
cardiomyocytes. Consequently the exchanger plays a critical role in the regulation of cellular …

Abstract Increased Na/Ca exchange (NCX) expression may be part of the genetic
reprogramming in cardiac remodeling. In this review we address the following questions:(1) …

Ca 2+ homeostasis is essential for cell function and survival. As such, the cytosolic Ca 2+
concentration is tightly controlled by a wide number of specialized Ca 2+ handling proteins …

Mobilization of endoplasmic reticulum Ca2+ is pivotal to the ability of a cell to send or
respond to stimuli. Ca2+–Mg2+-ATPases, termed SERCA pumps, sequester Ca2+ into the …