Biochemical and mechanical regulation of actin dynamics

P Lappalainen, T Kotila, A Jégou… - … Reviews Molecular Cell …, 2022 - nature.com
Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Mechanisms of clathrin-mediated endocytosis

M Kaksonen, A Roux - Nature reviews Molecular cell biology, 2018 - nature.com
Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Living material assembly of bacteriogenic protocells

C Xu, N Martin, M Li, S Mann - Nature, 2022 - nature.com
Advancing the spontaneous bottom-up construction of artificial cells with high organizational
complexity and diverse functionality remains an unresolved issue at the interface between …

Regulation of clathrin-mediated endocytosis

M Mettlen, PH Chen, S Srinivasan… - Annual review of …, 2018 - annualreviews.org
Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Phosphoinositides in control of membrane dynamics

KO Schink, KW Tan, H Stenmark - Annual review of cell and …, 2016 - annualreviews.org
Most functions of eukaryotic cells are controlled by cellular membranes, which are not static
entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively …

Condensation of Ede1 promotes the initiation of endocytosis

M Kozak, M Kaksonen - Elife, 2022 - elifesciences.org
Clathrin-mediated endocytosis is initiated by a network of weakly interacting proteins
through a poorly understood mechanism. Ede1, the yeast homolog of mammalian Eps15, is …

Actin and endocytosis in budding yeast

BL Goode, JA Eskin, B Wendland - Genetics, 2015 - academic.oup.com
Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

M Akamatsu, R Vasan, D Serwas, MA Ferrin… - Elife, 2020 - elifesciences.org
Force generation by actin assembly shapes cellular membranes. An experimentally
constrained multiscale model shows that a minimal branched actin network is sufficient to …

Systematic nanoscale analysis of endocytosis links efficient vesicle formation to patterned actin nucleation

M Mund, JA van Der Beek, J Deschamps, S Dmitrieff… - Cell, 2018 - cell.com
Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven
by a self-assembled macromolecular machine of over 50 different proteins in tens to …

A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats

M Saleem, S Morlot, A Hohendahl, J Manzi… - Nature …, 2015 - nature.com
In endocytosis, scaffolding is one of the mechanisms to create membrane curvature by
moulding the membrane into the spherical shape of the clathrin cage. However, the impact …