Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Cell surface sialosides constitute a central axis of immune modulation that is exploited by
tumors to evade both innate and adaptive immune destruction. Therapeutic strategies that …

Mucin domains are densely O-glycosylated modular protein domains that are found in a
wide variety of cell surface and secreted proteins. Mucin-domain glycoproteins are known to …

The profile of cell surface molecules, the biochemical platform for cellular communication,
can be likened to a molecular fingerprint. Historically, raising monoclonal antibodies by …

We have explored the fundamental biological processes by which complex carbohydrates
expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell …

Podoplanin is a transmembrane O-glycoprotein that binds to C-type lectin-like receptor 2
(CLEC-2). The O-glycan-dependent interaction seems to play crucial roles in various …

Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory
receptor that recognizes specific O-glycosylated proteins and is expressed on various innate …

Lectins, defined as proteins that recognize carbohydrates, perform numerous essential
biological functions. Recognizing a diverse array of carbohydrate structures, vertebrate …

Recent advancements in oncolytic virotherapy commend a special attention to developing
new strategies for targeting cancer cells with oncolytic viruses (OVs). Modifications of the …

Glycosylation of viral envelope proteins is important for infectivity and interaction with host
immunity, however, our current knowledge of the functions of glycosylation is largely limited …