Pharmacogenomic and pharmacotranscriptomic profiling of childhood acute lymphoblastic leukemia: paving the way to personalized treatment
Personalized medicine is focused on research disciplines which contribute to the
individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute …
individualization of therapy, like pharmacogenomics and pharmacotranscriptomics. Acute …
MicroRNAs and the diagnosis of childhood acute lymphoblastic leukemia: systematic review, meta-analysis and re-analysis with novel small RNA-seq tools
Simple Summary MicroRNAs (miRNAs) have been under the spotlight for the last three
decades. These non-coding RNAs seem to be dynamic regulators of mRNA stability and …
decades. These non-coding RNAs seem to be dynamic regulators of mRNA stability and …
Ontologies and knowledge graphs in oncology research
Simple Summary Cancer is a complex phenomenon and cancer research is increasingly
data-rich. Representing this knowledge in a manner that is both human and computer …
data-rich. Representing this knowledge in a manner that is both human and computer …
Non-coding RNAs as novel biomarkers in cancer drug resistance
H Yang, C Qi, B Li, L Cheng - Current Medicinal Chemistry, 2022 - ingentaconnect.com
Chemotherapy is often the primary and most effective anticancer treatment; however, drug
resistance remains a major obstacle to it being curative. Recent studies have demonstrated …
resistance remains a major obstacle to it being curative. Recent studies have demonstrated …
[HTML][HTML] B-cell acute lymphoblastic leukemia-related microRNAs: uncovering their diverse and special roles
M Lv, S Zhu, H Peng, Z Cheng, G Zhang… - American Journal of …, 2021 - ncbi.nlm.nih.gov
B-cell acute lymphoblastic leukemia (B-ALL) is a common type of hematologic malignancy
characterized by the uncontrolled growth of immature B lymphocytes. Genomics …
characterized by the uncontrolled growth of immature B lymphocytes. Genomics …
Model based on GA and DNN for prediction of mRNA-Smad7 expression regulated by miRNAs in breast cancer
E Manzanarez-Ozuna, DL Flores… - Theoretical Biology and …, 2018 - Springer
Abstract Background The Smad7 protein is negative regulator of the TGF-β signaling
pathway, which is upregulated in patients with breast cancer. miRNAs regulate proteins …
pathway, which is upregulated in patients with breast cancer. miRNAs regulate proteins …
Integrated bioinformatics analysis of the crucial candidate genes and pathways associated with glucocorticoid resistance in acute lymphoblastic leukemia
Y Chen, P Jiang, J Wen, Z Wu, J Li, Y Chen… - Cancer …, 2020 - Wiley Online Library
Glucocorticoids (GC) are the foundation of the chemotherapy regimen in acute
lymphoblastic leukemia (ALL). However, resistance to GC is observed more frequently than …
lymphoblastic leukemia (ALL). However, resistance to GC is observed more frequently than …
MiRNAs in hematopoiesis and acute lymphoblastic leukemia
DK Mendiola-Soto, DA Bárcenas-López… - International Journal of …, 2023 - mdpi.com
Acute lymphoblastic leukemia (ALL) is the most common kind of pediatric cancer. Although
the cure rates in ALL have significantly increased in developed countries, still 15–20% of …
the cure rates in ALL have significantly increased in developed countries, still 15–20% of …
Role of microRNAs in glucocorticoid‑resistant B‑cell precursor acute lymphoblastic leukemia
N Sakurai, Y Komada, R Hanaki… - Oncology …, 2019 - spandidos-publications.com
Acute lymphoblastic leukemia (ALL) is the most common malignant disorder in children and
intensive combination therapy has markedly improved patient prognosis. However, efficacy …
intensive combination therapy has markedly improved patient prognosis. However, efficacy …
[HTML][HTML] 索朗斯珠, 牛家强, 王玉恒, 贡嘎, 旦巴次仁, 席广银, 郭敏, 徐业芬
温东旭， 张雷 - 牦牛Nramp1 基因mRNA 组织表达谱及其相关miRNAs …, 2019 - xml-data.org
旨在探究牦牛Nramp1 基因mRNA 及可能靶定Nramp1 的miRNAs 组织表达谱. 本研究利用RT-
PCR 技术对牦牛Nramp1 基因的mRNA 组织表达谱进行分析, 同时运用TargentScan …
PCR 技术对牦牛Nramp1 基因的mRNA 组织表达谱进行分析, 同时运用TargentScan …