Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Neutrophils are the major circulating white blood cells in humans. They play an essential
role in host defense against pathogens. In healthy individuals, circulating neutrophils are in …

Neutrophils (also called polymorphonuclear leukocytes, PMNs) are the most abundant white
blood cells in humans and play a central role in innate host defense. Another distinguishing …

Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial
and viral products induces neutrophils to transition from a basal state into a primed one …

Neutrophil extracellular traps (NET s) are a recently discovered addition to the defensive
armamentarium of neutrophils, assisting in the immune response against rapidly dividing …

The reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is part of the
microbicidal arsenal used by human polymorphonuclear neutrophils (PMNs) to eradicate …

The proinflammatory cytokine tumor necrosis factor (TNF) is known to be expressed in brain
ischemia; however, its cellular and temporal appearance is not fully settled. In this study …

Neutrophil NADPH oxidase plays a key role in host defense and in inflammation by
releasing large amounts of superoxide and other ROSs. Proinflammatory cytokines such as …

Platelet-activating factor (PAF) is a potent proinflammatory phospholipid with diverse
pathological and physiological effects. This bioactive phospholipid mediates processes as …

Activated neutrophils play an important role in the pathogenesis of sepsis,
glomerulonephritis, acute renal failure, and other inflammatory processes. The resolution of …