Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors

JT Wan, DM Sheeley, MJ Somerman, JS Lee - Bone research, 2020 - nature.com
It is well established that alterations in phosphate metabolism have a profound effect on
hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the …

Comparison of isoflurane, ketamine–dexmedetomidine, and ketamine–xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris)

JM Jiron, JL Mendieta Calle, EJ Castillo… - Journal of the …, 2019 - ingentaconnect.com
Rice rats (Oryzomys palustris) are an unconventional laboratory species that has been used
to study photoperiodicity, periodontitis, and osteonecrosis of the jaw. Interventional …

Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris)

EJ Castillo, JG Messer, AM Abraham, JM Jiron… - Bone, 2021 - Elsevier
Introduction Osteonecrosis of the jaw (ONJ) is an adverse event that requires association of
both systemic risk factors, such as powerful anti-resorptives (pARs; eg zoledronic acid …

[HTML][HTML] Zoledronic acid increases the prevalence of medication-related osteonecrosis of the jaw in a dose dependent manner in rice rats (Oryzomys palustris) with …

JG Messer, JLM Calle, JM Jiron, EJ Castillo… - Bone, 2018 - Elsevier
Objective Investigate role of dose/duration of zoledronic acid (ZOL), a powerful anti-
resorptive (pAR), on prevalence of medication-related osteonecrosis of the jaw (MRONJ) in …

Zoledronate treatment duration is linked to bisphosphonate‐related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis

JG Messer, JM Jiron, JL Mendieta Calle… - Oral …, 2019 - Wiley Online Library
Objectives To determine the extent that zoledronate (ZOL) dose and duration is associated
with bisphosphonate‐related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with …

A New Way to Model Periodontitis in Laboratory Animals

D Moiseev, S Donskov, I Dubrovin, M Kulyukina… - Dentistry Journal, 2023 - mdpi.com
The prevalence of periodontal diseases is increasing, tends to increase with age and is
considered as one of the main causes of tooth loss. To assess the effectiveness of new …

Anti-vascular endothelial growth factor antibody monotherapy causes destructive advanced periodontitis in rice rats (Oryzomys palustris)

JG Messer, EJ Castillo, AM Abraham, JM Jiron, R Israel… - Bone, 2020 - Elsevier
Abstract Objective Angiogenesis inhibitors (AgI) are commonly used in combination
chemotherapy protocols to treat cancer, and have been linked to osteonecrosis of the jaw …

Intermittent parathyroid hormone enhances the healing of medication-related osteonecrosis of the jaw lesions in rice rats

EJ Castillo, JM Jiron, CS Croft, DG Freehill… - Frontiers in …, 2023 - frontiersin.org
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
in patients treated with antiresorptives. Management of MRONJ is challenging, and no non …

Increased anxiety-like behavior in the acute phase of a preclinical model of periodontal disease

BLR Varotto, RCR Martinez, FV Gouveia… - Frontiers in …, 2020 - frontiersin.org
Periodontal disease (PD) is an infectious-inflammatory oral disease that is highly prevalent
among adolescence and adulthood and can lead to chronic orofacial pain and be …