Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

Background PIM kinases are well-studied drug targets for cancer, belonging to
Serine/Threonine kinases family. They are the downstream target of various signaling …

PIM-1 kinase belongs to the Ser/Thr kinases family, an attractive therapeutic target for
prostate cancer. Here, we screened about 100 natural substances to find potential PIM-1 …

Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in
cells and play important roles in cancer progression. Selective degradation of gain-of …

Ovarian cancer continues to be the most lethal among gynecological malignancies and the
major cause for cancer-associated mortality among women. Limitations of current ovarian …

The PIM 1 protein is an important regulator of cell proliferation, the cell cycle, apoptosis, and
metabolism in various human cancers. Micro RNA s (mi RNA s) are powerful post …

PIM kinases have been shown to play a role in prostate cancer development and
progression, as well as in some of the hallmarks of cancer, especially proliferation and …

Protein kinase-mediated phosphorylation plays a critical role in many biological processes.
However, the identification of key regulatory kinases is still a great challenge. Here, we …

The ubiquitin-proteasome pathway (UPP) is the main non-lysosomal proteolytic system
responsible for degradation of most intracellular proteins, specifically damaged and …

Simple Summary Prostate cancer is the principal cause of cancer-related mortality in men.
While localized tumors can be successfully treated by orchiectomy or medical castration …