A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …
the host through recognition of distinct molecules, known as pathogen-or damage …
The NLR gene family: from discovery to present day
The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …
genes that were later grouped into the family were already known at that time. Although it is …
Programming inflammatory cell death for therapy
S Christgen, RE Tweedell, TD Kanneganti - Pharmacology & therapeutics, 2022 - Elsevier
Programmed cell death (PCD) is an essential part of organismal development and plays
fundamental roles in host defense against pathogens and the maintenance of homeostasis …
fundamental roles in host defense against pathogens and the maintenance of homeostasis …
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …
Caspases in cell death, inflammation, and disease
N Van Opdenbosch, M Lamkanfi - Immunity, 2019 - cell.com
Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …
involved in cell death and inflammation responses. A wealth of foundational insight into the …
Emerging activators and regulators of inflammasomes and pyroptosis
The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
Rare variant associations with plasma protein levels in the UK Biobank
Integrating human genomics and proteomics can help elucidate disease mechanisms,
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …
identify clinical biomarkers and discover drug targets,,–. Because previous proteogenomic …
Pediatric hemophagocytic lymphohistiocytosis
SW Canna, RA Marsh - Blood, The Journal of the American …, 2020 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
AC Aschenbrenner, M Mouktaroudi, B Krämer… - Genome medicine, 2021 - Springer
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers
of COVID-19 patients all over the world. Clinical presentations range from asymptomatic …
of COVID-19 patients all over the world. Clinical presentations range from asymptomatic …
COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy
SARS-CoV-2 infection is characterized by a protean clinical picture that can range from
asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display …
asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display …