[HTML][HTML] Fixing the GAP: The role of RhoGAPs in cancer

G Kreider-Letterman, NM Carr… - European journal of cell …, 2022 - Elsevier
Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

Downregulation of the Rho GTPase pathway abrogates resistance to ionizing radiation in wild-type p53 glioblastoma by suppressing DNA repair mechanisms

YT Magalhaes, VK Boell, GD Cardella, FL Forti - Cell Death & Disease, 2023 - nature.com
Glioblastoma (GBM), the most common aggressive brain tumor, is characterized by rapid
cellular infiltration and is routinely treated with ionizing radiation (IR), but therapeutic …

ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in modulating the malignant biological behavior of osteosarcoma cells

S Li, J Xue, H Zhang, G Shang - Journal of orthopaedic surgery and …, 2023 - Springer
Objective Osteosarcoma is a rare primary malignant tumor of the bone characterized by poor
survival rates, owing to its unclear pathogenesis. Rho GTPase-activating protein 44 …

[HTML][HTML] RICH2 decreases the mitochondrial number and affects mitochondrial localization in diffuse low-grade glioma-related epilepsy

J Zhang, L Gong, H Zhu, W Sun, J Tian, Y Zhang… - Neurobiology of …, 2023 - Elsevier
Epilepsy, a common complication of diffuse low-grade gliomas (DLGGs; diffuse
oligodendroglioma and astrocytoma collectively), severely compromises the quality of life of …

The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma

J Liu, H Ban, Y Liu, J Ni - Scientific reports, 2021 - nature.com
Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine
dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological …

ARHGAP44 expression is associated with the metastasis of osteosarcoma and is a promising prognostic biomarker

S Hu, W Wang - Journal of Orthopaedic Research®, 2023 - Wiley Online Library
Osteosarcoma (OS) is the most domain primary malignant bone tumor. Treatment
resistances and metastases result in a decreasing 5‐year overall survival rate of OS …

[HTML][HTML] Genome-wide association study for loin muscle area of commercial crossbred pigs

M Luan, D Ruan, Y Qiu, Y Ye, S Zhou, J Yang… - Animal …, 2023 - ncbi.nlm.nih.gov
Objective Loin muscle area (LMA) is an important target trait of pig breeding. This study
aimed to identify single nucleotide polymorphisms (SNPs) and genes associated with LMA …

A novel ARHGAP family gene signature for survival prediction in glioma patients

J Huang, G Wang, J Zhang, Y Liu… - Journal of Cellular …, 2024 - Wiley Online Library
ARHGAP family genes are often used as glioma oncogenic factors, and their mechanism of
action remains unexplained. Our research entailed a thorough examination of the immune …

[HTML][HTML] RICH2, a potential tumor suppressor in hepatocellular carcinoma

J Zhang, C Yang, L Gong, S Zhu, J Tian… - Frontiers in Bioscience …, 2019 - imrpress.com
Rho GTPase-activating proteins (RhoGAPs) are implicated in the development and
progression of hepatocellular carcinoma (HCC). We tested the idea that RICH2 is a tumor …

[Retracted] Identification of Key MicroRNAs and Genes between Colorectal Adenoma and Colorectal Cancer via Deep Learning on GEO Databases and …

X Zhang, M Jin, F Liu, H Qu… - Contrast Media & …, 2023 - Wiley Online Library
Background. Deep learning techniques are gaining momentum in medical research.
Colorectal adenoma (CRA) is a precancerous lesion that may develop into colorectal cancer …