Personalized medicine tailors therapies, disease prevention, and health maintenance to the
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …

The economic and health burden caused by adverse drug reactions has increased
dramatically in the last few years. This is likely to be mediated by increasing polypharmacy …

The seminal paper on the CYP2D6 Activity Score (AS) was first published ten years ago
and, since its introduction in 2008, it has been widely accepted in the field of …

Drug metabolism is a critical process for the removal of unwanted substances from the body.
In humans, approximately 80% of oxidative metabolism and almost 50% of the overall …

Pharmacogenomics, ie, the study of how an individual's genomic profile influences his or her
response to drugs, has emerged as a clinical tool to optimize drug therapy. Certain variants …

Abstract Background Pharmacogenomics (PGx) can provide valuable pharmacokinetic and
pharmacodynamic information for the pharmacist's assessment of drug therapy, especially …

Surveys among pharmacists and physicians show that these healthcare professionals have
successfully adopted the concept of pharmacogenomics (PGx). 1‐3 In addition, patients are …

Cytochrome P450 (CYP) 1A enzymes are considerably expressed in the human intestine
and liver and involved in the biotransformation of about 10% of marketed drugs. Despite this …

Pharmacotherapy for neuropsychiatric disorders, such as anxiety and depression, has been
characterized by significant inter-individual variability in drug response and the development …

Pharmacogenetic testing (PGT) is increasingly being used as a tool to guide clinical
decisions. This article describes the development of an outpatient, pharmacist-led …