Purification of Copper Radioisotopes for Medical Applications: Chromatographic Methods and Challenges

AI Fonseca, SJC Do Carmo, I Hrynchak… - Separation & …, 2024 - Taylor & Francis
Copper radioisotopes are gaining increasing significance for medical use in recent years for
both diagnostic and therapeutic applications. To answer the growing clinical demand, fast …

Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target Approach

I Hrynchak, D Cocioabă, AI Fonseca, R Leonte… - Molecules, 2023 - mdpi.com
Antibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being
proposed as theranostic tools in multiple human diseases. While the production of copper …

Cyclotron production of 64Cu by proton irradiation of enriched 64Ni target: Validation of Geant4 simulation parameters through experimental data

S Baruta, R Leonte, D Cocioaba, L Craciun… - Frontiers in …, 2022 - frontiersin.org
The use of radioisotopes in nuclear medicine applications became essential for the
diagnosis and follow-up imaging of many oncological, cardiovascular, and …

Modifications in cellular viability, DNA damage and stress responses inflicted in cancer cells by copper-64 ions

RM Serban, D Niculae, G Manda, I Neagoe… - Frontiers in …, 2023 - frontiersin.org
Due to combined therapeutical emissions, a high linear energy transfer Auger-electrons with
the longer ranged β− particles, 64Cu-based radiopharmaceuticals raise particular …

[HTML][HTML] Neurotensin (8-13) and Neuromedin N Neuropeptides Radiolabelling with Copper-64 Produced on Solid or Liquid Targets

D Cocioabă, AI Fonseca, R Leonte, I Hrynchak… - Molecules, 2024 - mdpi.com
On the verge of a theranostic approach to personalised medicine, copper-64 is one of the
emerging radioisotopes in nuclear medicine due to its exploitable nuclear and biochemical …

Medical radioisotope 89Zr production with RFT-30 cyclotron

JY Lee, MG Hur, YB Kong, EJ Lee, SD Yang… - … of Radioanalytical and …, 2021 - Springer
Abstract 89 Zr is an emerging radionuclide with promising application in nuclear medicine
for the non-invasive diagnosis of various cancers with PET imaging. This paper would …

[PDF][PDF] VALIDATION OF A HEADSPACE GAS CHROMATOGRAPHY METHOD FOR VOLATILE RESIDUAL SOLVENTS IDENTIFICATION IN …

MR TUDOROIU-CORNOIU, EL CHILUG, ION Ion… - scientificbulletin.upb.ro
The following study presents the development and validation of a headspace gas
chromatography (HS-GC) analytical method for determining five residual solvents, frequently …