From pre-diabetes to diabetes: diagnosis, treatments and translational research

RMM Khan, ZJY Chua, JC Tan, Y Yang, Z Liao, Y Zhao - Medicina, 2019 - mdpi.com
Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time.
According to the 2017 International Diabetes Federation (IDF) statistics, the global …

Metabolic implications of pancreatic fat accumulation

R Wagner, SS Eckstein, H Yamazaki, F Gerst… - Nature Reviews …, 2022 - nature.com
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …

Effects of accelerometer-based sedentary time and physical activity on DEXA-measured fat mass in 6059 children

AO Agbaje, W Perng, TP Tuomainen - Nature Communications, 2023 - nature.com
Globally, childhood obesity is on the rise and the effect of objectively measured movement
behaviour on body composition remains unclear. Longitudinal and causal mediation …

Update on the effects of physical activity on insulin sensitivity in humans

SR Bird, JA Hawley - BMJ open sport & exercise medicine, 2017 - bmjopensem.bmj.com
Purpose and methods This review presents established knowledge on the effects of physical
activity (PA) on whole-body insulin sensitivity (SI) and summarises the findings of recent …

Klotho, aging, and the failing kidney

S Buchanan, E Combet, P Stenvinkel… - Frontiers in …, 2020 - frontiersin.org
Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

[HTML][HTML] Lack of exercise is a major cause of chronic diseases

FW Booth, CK Roberts, MJ Laye - Comprehensive physiology, 2012 - ncbi.nlm.nih.gov
Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause
of most chronic diseases. The initial third of the article considers: activity and prevention …

[HTML][HTML] Preventive role of diet interventions and dietary factors in type 2 diabetes mellitus: an umbrella review

PL Toi, T Anothaisintawee, JR Briones, S Reutrakul… - Nutrients, 2020 - mdpi.com
Background: Although the body of evidence indicates clear benefits of dietary modifications
for prevention of type-2 diabetes mellitus (T2DM), it may be difficult for healthcare providers …

Lifestyle and the prevention of type 2 diabetes: a status report

KI Galaviz, KMV Narayan, F Lobelo… - American journal of …, 2018 - journals.sagepub.com
Diabetes is a costly disease affecting 387 million individuals globally and 28 million in the
United States. Its precursor, prediabetes, affects 316 and 86 million individuals globally and …

What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review

M Chimen, A Kennedy, K Nirantharakumar, TT Pang… - Diabetologia, 2012 - Springer
Physical activity improves well-being and reduces the risk of heart disease, cancer and type
2 diabetes mellitus in the general population. In individuals with established type 2 diabetes …

[HTML][HTML] Exercise induces tissue-specific adaptations to enhance cardiometabolic health

SP Ashcroft, B Stocks, B Egan, JR Zierath - Cell metabolism, 2024 - cell.com
The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause
mortality is decreased in individuals who meet the current recommendations for physical …