Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids

KA Seely, J Lapoint, JH Moran, L Fattore - Progress in Neuro …, 2012 - Elsevier
“K2” and “Spice” drugs (collectively hereafter referred to as Spice) represent a relatively new
class of designer drugs that have recently emerged as popular alternatives to marijuana …

Beyond THC: the new generation of cannabinoid designer drugs

L Fattore, W Fratta - Frontiers in behavioral neuroscience, 2011 - frontiersin.org
Synthetic cannabinoids are functionally similar to delta9-tetrahydrocannabinol (THC), the
psychoactive principle of cannabis, and bind to the same cannabinoid receptors in the brain …

Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex

C Xing, Y Zhuang, TH Xu, Z Feng, XE Zhou, M Chen… - Cell, 2020 - cell.com
Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders,
inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The …

[PDF][PDF] Pharmacology, toxicology, and adverse effects of synthetic cannabinoid drugs

SMR Gurney, KS Scott, SL Kacinko, BC Presley… - Forensic Sci …, 2014 - chm.uri.edu
Synthetic cannabinoid drugs have become an established part of the recreational drug
landscape in the United States and internationally. These drugs are manufactured in …

Spicing things up: synthetic cannabinoids

M Spaderna, PH Addy, DC D'Souza - Psychopharmacology, 2013 - Springer
Rationale Recently, products containing synthetic cannabinoids, collectively referred to as
Spice, are increasingly being used recreationally. Objectives The availability, acute …

Synthetic cannabinoids

B Mills, A Yepes, K Nugent - The American journal of the medical sciences, 2015 - Elsevier
Synthetic cannabinoids (SCBs), also known under the brand names of “Spice,”“K2,”“herbal
incense,”“Cloud 9,”“Mojo” and many others, are becoming a large public health concern due …

Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: mechanism underlying greater toxicity?

WE Fantegrossi, JH Moran, A Radominska-Pandya… - Life sciences, 2014 - Elsevier
K2 or Spice products are emerging drugs of abuse that contain synthetic cannabinoids
(SCBs). Although assumed by many teens and first time drug users to be a “safe” and “legal” …

[HTML][HTML] Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines

A Zgair, JCM Wong, JB Lee, J Mistry… - American journal of …, 2016 - ncbi.nlm.nih.gov
There has been an escalating interest in the medicinal use of Cannabis sativa in recent
years. Cannabis is often administered orally with fat-containing foods, or in lipid-based …

“Spiceophrenia”: a systematic overview of “Spice”‐related psychopathological issues and a case report

D Papanti, F Schifano, G Botteon… - Human …, 2013 - Wiley Online Library
Objectives The use of synthetic cannabimimetics (SC;“spice” drugs) is increasing, especially
among teenagers and young adults. In parallel with this, the number of studies describing …

Neuropharmacology of new psychoactive substances (NPS): focus on the rewarding and reinforcing properties of cannabimimetics and amphetamine-like stimulants

C Miliano, G Serpelloni, C Rimondo, M Mereu… - Frontiers in …, 2016 - frontiersin.org
New psychoactive substances (NPS) are a heterogeneous and rapidly evolving class of
molecules available on the global illicit drug market (eg smart shops, internet,“dark net”) as a …