Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …

Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques,
neurofibrillary tangles, and neuronal loss, accompanied by neuroinflammation …

The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human
biology. However, when ROS generation exceeds endogenous antioxidant capacity …

Skin aging is associated with the accumulation of senescent cells and is related to many
pathological changes, including decreased protection against pathogens, increased …