Implications of the hybrid epithelial/mesenchymal phenotype in metastasis
Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …
Bacterial small RNA regulators: versatile roles and rapidly evolving variations
S Gottesman, G Storz - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Small RNA regulators (sRNAs) have been identified in a wide range of bacteria and found to
play critical regulatory roles in many processes. The major families of sRNAs include true …
play critical regulatory roles in many processes. The major families of sRNAs include true …
MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination
Forward and backward transitions between epithelial and mesenchymal phenotypes play
crucial roles in embryonic development and tissue repair. Aberrantly regulated transitions …
crucial roles in embryonic development and tissue repair. Aberrantly regulated transitions …
Integration of bacterial small RNAs in regulatory networks
M Nitzan, R Rehani, H Margalit - Annual review of biophysics, 2017 - annualreviews.org
Small RNAs (sRNAs) are central regulators of gene expression in bacteria, controlling target
genes posttranscriptionally by base pairing with their mRNAs. sRNAs are involved in many …
genes posttranscriptionally by base pairing with their mRNAs. sRNAs are involved in many …
[HTML][HTML] A 3′ external transcribed spacer in a tRNA transcript acts as a sponge for small RNAs to prevent transcriptional noise
D Lalaouna, MC Carrier, S Semsey, JS Brouard… - Molecular cell, 2015 - cell.com
During ribosomal and transfer RNA maturation, external transcribed spacer (ETS) and
internal transcribed spacer (ITS) sequences are excised and, as non-functional by-products …
internal transcribed spacer (ITS) sequences are excised and, as non-functional by-products …
Base pairing small RNAs and their roles in global regulatory networks
Bacteria use a range of RNA regulators collectively termed small RNAs (sRNAs) to help
respond to changes in the environment. Many sRNAs regulate their target mRNAs through …
respond to changes in the environment. Many sRNAs regulate their target mRNAs through …
Simplified models of biological networks
The function of living cells is controlled by complex regulatory networks that are built of a
wide diversity of interacting molecular components. The sheer size and intricacy of …
wide diversity of interacting molecular components. The sheer size and intricacy of …
Multiple factors dictate target selection by Hfq‐binding small RNAs
Hfq‐binding small RNAs (sRNAs) in bacteria modulate the stability and translational
efficiency of target mRNAs through limited base‐pairing interactions. While these sRNAs are …
efficiency of target mRNAs through limited base‐pairing interactions. While these sRNAs are …
Structurally robust biological networks
F Blanchini, E Franco - BMC systems biology, 2011 - Springer
Background The molecular circuitry of living organisms performs remarkably robust
regulatory tasks, despite the often intrinsic variability of its components. A large body of …
regulatory tasks, despite the often intrinsic variability of its components. A large body of …
Conditional cooperativity of toxin-antitoxin regulation can mediate bistability between growth and dormancy
I Cataudella, K Sneppen, K Gerdes… - PLoS computational …, 2013 - journals.plos.org
Many toxin-antitoxin operons are regulated by the toxin/antitoxin ratio by mechanisms
collectively coined “conditional cooperativity”. Toxin and antitoxin form heteromers with …
collectively coined “conditional cooperativity”. Toxin and antitoxin form heteromers with …