The liver is unique in its ability to regenerate from a wide range of injuries and diseases.
Liver regeneration centers around hepatocyte proliferation and requires the coordinated …

Chronic liver inflammation, a pervasive global health issue, results in millions of annual
deaths due to its progression from fibrosis to the more severe forms of cirrhosis and …

Conclusions: This study indicates that DOCK2 controls CD8+ T-cell infiltration in HCC, and
cholesterol sulfate synthesized by sulfotransferase 2B1 in tumor cells promotes effector T …

The efficacy of HCC (hepatocellular carcinoma) immunotherapy is hindered by the limited
reactivity and short duration of tumor-infiltrating T cells. These deficiencies may be ascribed …

Background Allogeneic hepatocyte transplantation is an emerging approach to treat acute
liver defects. However, durable engraftment of the transplanted cells remains a daunting …

Abstract Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded
protein response (UPR), plays a role in the pathogenesis of several diseases, including …

This study is aimed at evaluating the effects of heat-killed Lactobacillus plantarum (L.
plantarum) on cholestatic liver injury induced by bile duct ligation (BDL) in rats. Rats in the …

Liver fibrosis develops as a result of severe liver damage and is considered a major clinical
concern throughout the world. Many factors are crucial for liver fibrosis progression. While …

Hepatic stellate cells (HSCs) are crucial for liver injury repair and cirrhosis. However, the
mechanism of chemotactic recruitment of HSCs into injury loci is still largely unknown. Here …

Organs and tissues contain a large number of tissue-resident macrophages (MΦ-Ts), which
are essential for regulating homeostasis and ensuring a rapid response to injury. However …