Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem
cells (CSCs), a subset of cells within the tumor with the potential for self-renewal …

Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

Cancers originally develop from normal cells that gain the ability to proliferate aberrantly and
eventually turn malignant. These cancerous cells then grow clonally into tumors and …

Genetic mutations that affect telomerase function or telomere maintenance result in a variety
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …

Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …

RNA-binding proteins (RBPs) control all aspects of RNA fate, and defects in their function
underlie a broad spectrum of human pathologies. We focus here on two recent studies that …

Dyskeratosis congenita is a premature aging syndrome characterized by muco-cutaneous
features and a range of other abnormalities, including early greying, dental loss …

Dyskeratosis congenita (DC) is characterized by multiple features including mucocutaneous
abnormalities, bone marrow failure and an increased predisposition to cancer. It exhibits …

Background Telomerase is an enzyme specialized in maintaining telomere lengths in highly
proliferative cells. Loss-of-function mutations cause critical telomere shortening and are …