The promises and perils of psychedelic pharmacology for psychiatry

TD McClure-Begley, BL Roth - Nature Reviews Drug Discovery, 2022 - nature.com
Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …

Models of psychedelic drug action: modulation of cortical-subcortical circuits

MK Doss, MB Madden, A Gaddis, MB Nebel… - Brain, 2022 - academic.oup.com
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Attenuation of antidepressant effects of ketamine by opioid receptor antagonism

NR Williams, BD Heifets, C Blasey… - American Journal of …, 2018 - Am Psychiatric Assoc
Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces
opioid system activation. The objective of this study was to determine whether opioid …

Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction

A Garcia-Romeu, R R. Griffiths… - Current drug abuse …, 2014 - benthamdirect.com
Psilocybin-occasioned mystical experiences have been linked to persisting effects in healthy
volunteers including positive changes in behavior, attitudes, and values, and increases in …

Current perspectives on psychedelic therapy: use of serotonergic hallucinogens in clinical interventions

A Garcia-Romeu, WA Richards - International Review of Psychiatry, 2018 - Taylor & Francis
Humans have used serotonergic hallucinogens (ie psychedelics) for spiritual, ceremonial,
and recreational purposes for thousands of years, but their administration as part of a …

[HTML][HTML] Looking for the self: phenomenology, neurophysiology and philosophical significance of drug-induced ego dissolution

R Millière - Frontiers in human neuroscience, 2017 - frontiersin.org
There is converging evidence that high doses of hallucinogenic drugs can produce
significant alterations of self-experience, described as the dissolution of the sense of self …

Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum …

CD Rosenbaum, SP Carreiro, KM Babu - Journal of medical toxicology, 2012 - Springer
Despite their widespread Internet availability and use, many of the new drugs of abuse
remain unfamiliar to health care providers. The herbal marijuana alternatives, like K2 or …

Clinical applications of hallucinogens: A review.

A Garcia-Romeu, B Kersgaard… - Experimental and clinical …, 2016 - psycnet.apa.org
Hallucinogens fall into several different classes, as broadly defined by pharmacological
mechanism of action, and chemical structure. These include psychedelics, entactogens …

Drug models of schizophrenia

H Steeds, RL Carhart-Harris… - Therapeutic advances in …, 2015 - journals.sagepub.com
Schizophrenia is a complex mental health disorder with positive, negative and cognitive
symptom domains. Approximately one third of patients are resistant to currently available …

The Altered States Database: Psychometric data from a systematic literature review

J Prugger, E Derdiyok, J Dinkelacker, C Costines… - Scientific data, 2022 - nature.com
In this paper, we present the development of the Altered States Database (ASDB), an open-
science project based on a systematic literature review. The ASDB contains psychometric …