Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

The novel object recognition test (NOR) test is a two trial cognitive paradigm that assesses
recognition memory. Recognition memory is disturbed in a range of human disorders and …

Mood and anxiety disorders are prevalent conditions affecting one out of four people during
lifetime. The development of high validity animal models to study these disorders has been a …

Neuregulin 1 (NRG-1) and its receptor ErbB4 have emerged as biologically plausible
schizophrenia risk factors, modulators of GABAergic and dopaminergic neurotransmission …

Patients with schizophrenia are at an increased risk for the development of depression.
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …

Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical
component in the pathophysiology of schizophrenia. However, the arrival of the genome …

Schizophrenia is a complex mental disorder that displays behavioral deficits such as
decreased sensory gating, reduced social interaction and working memory deficits. The …

Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been
reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We …

Schizophrenia has long been considered as a disorder with multifactorial origins. Recent
discoveries have advanced our understanding of the genetic architecture of the disease …

GABAergic interneurons of the cerebral cortex (cINs) play crucial roles in many aspects of
cortical function. The diverse types of cINs are classified into subgroups according to their …