The degree of frailty as a translational measure of health in aging
Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …
outcomes. We review how the degree of frailty conditions the development of late-life …
Determination of biological age: geriatric assessment vs biological biomarkers
LWM Diebel, K Rockwood - Current oncology reports, 2021 - Springer
Abstract Purpose of Review Biological age is the concept of using biophysiological
measures to more accurately determine an individual's age-related risk of adverse …
measures to more accurately determine an individual's age-related risk of adverse …
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here …
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here …
Measuring frailty in Medicare data: development and validation of a claims-based frailty index
Background Frailty is a key determinant of health status and outcomes of health care
interventions in older adults that is not readily measured in Medicare data. This study aimed …
interventions in older adults that is not readily measured in Medicare data. This study aimed …
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
Development is tightly connected to aging, but whether pharmacologically targeting
development can extend life remains unknown. Here, we subjected genetically diverse …
development can extend life remains unknown. Here, we subjected genetically diverse …
[HTML][HTML] Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults
PJ Larson, W Zhou, A Santiago, S Driscoll, E Fleming… - Nature aging, 2022 - nature.com
Older adults represent a vulnerable population with elevated risk for numerous morbidities.
To explore the association of the microbiome with aging and age-related susceptibilities …
To explore the association of the microbiome with aging and age-related susceptibilities …
Fifteen years of progress in understanding frailty and health in aging
K Rockwood, SE Howlett - BMC medicine, 2018 - Springer
The notion of frailty has evolved for more than 15 years. Although there is no consensus
definition, frailty reflects a state of increased vulnerability to adverse health outcomes for …
definition, frailty reflects a state of increased vulnerability to adverse health outcomes for …
[HTML][HTML] Age-related deficit accumulation and the diseases of ageing
K Rockwood, SE Howlett - Mechanisms of ageing and development, 2019 - Elsevier
With ageing, the potency of individual risk factors traditionally associated with common
illnesses declines. Instead, it is becoming clear that the impact of a wide range of age …
illnesses declines. Instead, it is becoming clear that the impact of a wide range of age …
[HTML][HTML] Dietary genistein increases microbiota-derived short chain fatty acid levels, modulates homeostasis of the aging gut, and extends healthspan and lifespan
Age-related gastrointestinal decline contributes to whole-organism frailty and mortality.
Genistein is known to have beneficial effects on age-related diseases, but its precise role in …
Genistein is known to have beneficial effects on age-related diseases, but its precise role in …
Age and life expectancy clocks based on machine learning analysis of mouse frailty
The identification of genes and interventions that slow or reverse aging is hampered by the
lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty …
lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty …