Isoflavones: anti-inflammatory benefit and possible caveats

J Yu, X Bi, B Yu, D Chen - Nutrients, 2016 - mdpi.com
Inflammation, a biological response of body tissues to harmful stimuli, is also known to be
involved in a host of diseases, such as obesity, atherosclerosis, rheumatoid arthritis, and …

Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence

L Chen, H Teng, Z Jia, M Battino, A Miron… - Critical reviews in …, 2018 - Taylor & Francis
Dietary flavonoids, which occur in many plant foods, are considered as the most active
constituents among the plant-derived ones in vitro and in vivo. To date, many studies have …

Pharmacokinetics, pharmacodynamics, toxicity, and formulations of daidzein: An important isoflavone

AP Laddha, YA Kulkarni - Phytotherapy Research, 2023 - Wiley Online Library
Abstract Daidzein, 7‐hydroxy‐3‐(4‐hydroxyphenyl)‐4H‐chromen‐4‐one is a naturally
occurring compound present in leguminous plants, especially in soybeans. Chemically it …

[PDF][PDF] The effects of dietary flavonoids on the regulation of redox inflammatory networks

V Izzi, L Masuelli, I Tresoldi, P Sacchetti… - Front Biosci …, 2012 - article.imrpress.com
Introduction 3. The biogenesis of reactive oxygen and nitrogen species 3.1. Reactive oxygen
species (ROS) 3.2. Reactive nitrogen species (RNS) 4. ROS and RNS as immune effectors …

Dietary flavonoids: molecular mechanisms of action as anti-inflammatory agents

L Marzocchella, M Fantini, M Benvenuto… - Recent patents on …, 2011 - ingentaconnect.com
Flavonoids are a large group of polyphenolic compounds, which are ubiquitously expressed
in plants. They are grouped according to their chemical structure and function into flavonols …

Luteolin inhibits ROS-activated MAPK pathway in myocardial ischemia/reperfusion injury

D Yu, M Li, Y Tian, J Liu, J Shang - Life Sciences, 2015 - Elsevier
Aims Luteolin is a falconoid compound that has an antioxidant effect, but its contribution to
ROS-activated MAPK pathways in ischemia/reperfusion injury is seldom reported. Here, we …

Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection

A Guru, G Sudhakaran, M Velayutham… - … and Physiology Part C …, 2022 - Elsevier
This study investigates the therapeutic activity of daidzein, an isoflavone that occurs
naturally in plants and herbs, against gentamicin-induced nephrotoxicity in Madin-Darby …

Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia

H Qiao, X Zhang, C Zhu, L Dong, L Wang, X Zhang… - Brain research, 2012 - Elsevier
BACKGROUND: Inflammatory damage is known to be involved in ischemic stroke. Luteolin
has been proved to elicit a series of biologic effects through its anti-inflammatory property in …

Daidzein: A review of pharmacological effects

MY Sun, Y Ye, L Xiao, K Rahman, W Xia… - African journal of …, 2016 - ajol.info
Background: Daidzein is an isoflavone with extensive nutritious value and is mainly
extracted from soy plants. It is also called phytoestrogen due to its structural similarity to the …

Pharmaceutical properties of calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali

JQ Gao, ZJ Liu, T Chen, DQ Zhao - Pharmaceutical biology, 2014 - Taylor & Francis
Abstract Context: Radix astragali (Fabaceae astragalus propinquus Schischkin) is a
Chinese medicinal herb traditionally used for the treatment of several diseases. Calycosin is …