[HTML][HTML] Cellular and molecular biology of sirtuins in cardiovascular disease

YP Liu, R Wen, CF Liu, TN Zhang, N Yang - Biomedicine & …, 2023 - Elsevier
Sirtuins (SIRTs) are a nicotinic adenine dinucleotide (+)-dependent histone deacetylase that
regulates critical signaling pathways in prokaryotes and eukaryotes. Studies have identified …

CTRP family in diseases associated with inflammation and metabolism: molecular mechanisms and clinical implication

H Zhang, Z Zhang-Sun, C Xue, X Li, J Ren… - Acta Pharmacologica …, 2023 - nature.com
C1q/tumor necrosis factor (TNF) related proteins (CTRPs) is a newly discovered adipokine
family with conservative structure and ubiquitous distribution and is secreted by adipose …

Knockdown of lncRNA PVT1 attenuated macrophage M1 polarization and relieved sepsis induced myocardial injury via miR-29a/HMGB1 axis

YY Luo, ZQ Yang, XF Lin, FL Zhao, HT Tu, LJ Wang… - Cytokine, 2021 - Elsevier
Background LncRNA PVT1 was reported to be elevated in septic myocardial tissue. The
underlying mechanism by which PVT1 aggravated sepsis induced myocardial injury needs …

CTRP1 aggravates cardiac dysfunction post myocardial infarction by modulating TLR4 in macrophages

Y Gu, X Hu, PB Ge, Y Chen, S Wu… - Frontiers in …, 2021 - frontiersin.org
CTRP1 (C1q/TNF-α [tumour necrosis factor-α]-related protein 1), an adiponectin paralog, is
associated with diabetes and adverse events in cardiovascular disease. However, its effect …

Uncovering the Molecular Mechanism of the Qiang‐Xin 1 Formula on Sepsis‐Induced Cardiac Dysfunction Based on Systems Pharmacology

S He, J Zhao, X Xu, X Cui, N Wang… - Oxidative Medicine …, 2020 - Wiley Online Library
Cardiac dysfunction is a critical manifestation of sepsis‐induced multiorgan failure and
results in the high mortality of sepsis. Our previous study demonstrated that a traditional …

CTRP1 prevents high fat diet-induced obesity and improves glucose homeostasis in obese and STZ-induced diabetic mice

M Ren, J Pan, X Yu, K Chang, X Yuan… - Journal of Translational …, 2022 - Springer
Background C1q/tumor necrosis factor-related protein 1 (CTRP1) is an adipokine secreted
by adipose tissue, related to chondrocyte proliferation, inflammation, and glucose …

RETRACTED: Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis

Y Zhu, A Sun, T Meng, H Li - 2020 - Elsevier
Contents lists available at ScienceDirect Life Sciences journal homepage: www. elsevier.
com/locate/lifescie Protective role of long noncoding RNA CRNDE in myocardial tissues …

Protective role of lncRNA TTN-AS1 in sepsis-induced myocardial injury via miR-29a/E2F2 axis

X Pei, Y Wu, H Yu, Y Li, X Zhou, Y Lei, W Lu - Cardiovascular drugs and …, 2022 - Springer
Objective Approximately 50% of patients with sepsis encounter myocardial injury. The
mortality of septic patients with cardiac dysfunction (approx. 70%) is much higher than that of …

Sirtuin 1 deletion increases inflammation and mortality in sepsis

HE Labiner, KM Sas, JA Baur… - Journal of Trauma and …, 2022 - journals.lww.com
BACKGROUND Sepsis is a hyperinflammatory response to infection that can lead to
multiorgan failure and eventually death. Often, the onset of multiorgan failure is heralded by …

NRF2 inhibits cardiomyocyte pyroptosis via regulating CTRP1 in sepsis-induced myocardial injury

Y Teng, N Li, Y Wang, S Sun, J Hou, Y Chen, H Pan - Shock, 2022 - journals.lww.com
C1q/tumor necrosis factor-related protein 1 (CTRP1) has been demonstrated as a crucial
regulator in myocardial injury (MI). The present study aims to evaluate the mechanism of …