The development and progression of cardiovascular disease (CVD) can mainly be attributed
to the narrowing of blood vessels caused by atherosclerosis and thrombosis, which induces …

Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and
constitutes a central pathophysiological process that underlies tissue dysfunction, across …

Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by
the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular …

Background The molecular drivers of early sporadic Parkinson's disease (PD) remain
unclear, and the presence of widespread end stage pathology in late disease masks the …

Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart
disease. While≈ 50% of patients with HCM carry a sarcomere gene mutation (sarcomere …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere
protein-encoding genes (ie genotype-positive HCM). In an increasing number of patients …

Background: Defects in energetics are thought to be central to the pathophysiology of
hypertrophic cardiomyopathy (HCM); yet, the determinants of ATP availability are not known …

Poor access to human left ventricular myocardium is a significant limitation in the study of
heart failure (HF). Here, we utilise a carefully procured large human heart biobank of …

Mitochondria have diverse functions critical to whole-body metabolic homeostasis.
Endurance training alters mitochondrial activity, but systematic characterization of these …

Background: Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left
ventricular hypertrophy. Currently, hypertrophy pathways responsible for HCM have not …