Most common neurodegenerative diseases feature deposition of protein amyloids and
degeneration of brain networks. Amyloids are ordered protein assemblies that can act as …

Many non-infectious neurodegenerative diseases are associated with the accumulation of
fibrillar proteins. These diseases all exhibit features that are reminiscent of those of …

Tauopathies are neurodegenerative diseases characterized by aggregation of the
microtubule-associated protein Tau in neurons and glia. Although Tau is normally …

Exosomes are small membranous vesicles secreted by a number of cell types including
neurons and can be isolated from conditioned cell media or bodily fluids such as urine and …

Deposition of proteins of aberrant conformation is the hallmark of many neurodegenerative
diseases. Misfolding of the normally globular mutant superoxide dismutase-1 (SOD1) is a …

Abstract In variant Creutzfeldt–Jakob disease, prions (PrPSc) enter the body with
contaminated foodstuffs and can spread from the intestinal entry site to the central nervous …

The most common neurodegenerative diseases, including Alzheimer's disease and
Parkinson's disease, are characterized by the misfolding of a small number of proteins that …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Extracellular vesicles, including exosomes, are small membranous vesicles released from
many biotypes, contributing to the disease progression and spreading. These extracellular …

Transcellular propagation of protein aggregate" seeds" has been proposed to mediate the
progression of neurodegenerative diseases in tauopathies and α-synucleinopathies. We …