DREADDs for neuroscientists
BL Roth - Neuron, 2016 - cell.com
To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …
normal and pathological brain function. In this regard, chemogenetic technologies represent …
Genetic dissection of neural circuits: a decade of progress
Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …
Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
Recent findings in human samples and animal models support the involvement of
inflammation in the development of Parkinson's disease. Nevertheless, it is currently …
inflammation in the development of Parkinson's disease. Nevertheless, it is currently …
Concurrent activation of striatal direct and indirect pathways during action initiation
The basal ganglia are subcortical nuclei that control voluntary actions, and they are affected
by a number of debilitating neurological disorders,,,. The prevailing model of basal ganglia …
by a number of debilitating neurological disorders,,,. The prevailing model of basal ganglia …
Adult restoration of Shank3 expression rescues selective autistic-like phenotypes
Because autism spectrum disorders are neurodevelopmental disorders and patients
typically display symptoms before the age of three, one of the key questions in autism …
typically display symptoms before the age of three, one of the key questions in autism …
DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility
DJ Urban, BL Roth - Annual review of pharmacology and …, 2015 - annualreviews.org
In the past decade, emerging synthetic biology technologies such as chemogenetics have
dramatically transformed how pharmacologists and systems biologists deconstruct the …
dramatically transformed how pharmacologists and systems biologists deconstruct the …
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A
SJ Hatsell, V Idone, DMA Wolken, L Huang… - Science translational …, 2015 - science.org
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by
episodically exuberant heterotopic ossification (HO), whereby skeletal muscle is abnormally …
episodically exuberant heterotopic ossification (HO), whereby skeletal muscle is abnormally …
High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level
The precise annotation and accurate identification of neural structures are prerequisites for
studying mammalian brain function. The orientation of neurons and neural circuits is usually …
studying mammalian brain function. The orientation of neurons and neural circuits is usually …
T-Scan: a genome-wide method for the systematic discovery of T cell epitopes
T Kula, MH Dezfulian, CI Wang, NS Abdelfattah… - Cell, 2019 - cell.com
T cell recognition of specific antigens mediates protection from pathogens and controls
neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their …
neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their …
A student's guide to neural circuit tracing
C Saleeba, B Dempsey, S Le, A Goodchild… - Frontiers in …, 2019 - frontiersin.org
The mammalian nervous system is comprised of a seemingly infinitely complex network of
specialized synaptic connections that coordinate the flow of information through it. The field …
specialized synaptic connections that coordinate the flow of information through it. The field …