The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …
[HTML][HTML] TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease
Transforming growth factor-beta (TGF-β) and bone morphogenic protein (BMP) signaling
has fundamental roles in both embryonic skeletal development and postnatal bone …
has fundamental roles in both embryonic skeletal development and postnatal bone …
Generation of small RNA-modulated exosome mimetics for bone regeneration
Administration of exosomes is considered an attractive cell-free approach to skeletal repair
and pathological disease treatment. However, poor yield for the production technique and …
and pathological disease treatment. However, poor yield for the production technique and …
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone
SK Ramasamy, AP Kusumbe, L Wang, RH Adams - Nature, 2014 - nature.com
Blood vessel growth in the skeletal system and osteogenesis seem to be coupled,
suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells …
suggesting the existence of molecular crosstalk between endothelial and osteoblastic cells …
[HTML][HTML] TGF-β and BMP signaling in osteoblast differentiation and bone formation
Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is
involved in a vast majority of cellular processes and is fundamentally important throughout …
involved in a vast majority of cellular processes and is fundamentally important throughout …
Bone morphogenetic proteins
DI Chen, M Zhao, GR Mundy - Growth factors, 2004 - Taylor & Francis
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …
TGF-β family signaling in mesenchymal differentiation
I Grafe, S Alexander, JR Peterson… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …
and also contribute to tissue homeostasis and regeneration, although the requirements for …
The BMP pathway and its inhibitors in the skeleton
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming
growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context …
growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context …
Haematopoietic stem cell release is regulated by circadian oscillations
Haematopoietic stem cells (HSCs) circulate in the bloodstream under steady-state
conditions, but the mechanisms controlling their physiological trafficking are unknown. Here …
conditions, but the mechanisms controlling their physiological trafficking are unknown. Here …
Skeletal remodeling in health and disease
M Zaidi - Nature medicine, 2007 - nature.com
The use of genetically manipulated mouse models, gene and protein discovery and the
cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal …
cataloguing of genetic mutations have each allowed us to obtain new insights into skeletal …