The role of innate immune cells in the tumor microenvironment and research progress in anti-tumor therapy

C Lu, Y Liu, NM Ali, B Zhang, X Cui - Frontiers in Immunology, 2023 - frontiersin.org
Innate immune cells in the tumor microenvironment (TME) mainly include macrophages,
neutrophils, natural killer cells, dendritic cells and bone marrow derived suppressor cells …

Two-faced roles of tumor-associated neutrophils in cancer development and progression

N Mukaida, S Sasaki, T Baba - International Journal of Molecular …, 2020 - mdpi.com
Neutrophils are the most abundant circulating leukocytes in humans. Neutrophil infiltration
into tumor tissues has long been observed but its roles have been ignored due to the …

Immune microenvironment composition in non‐small cell lung cancer and its association with survival

M Tamminga, TJN Hiltermann… - Clinical & …, 2020 - Wiley Online Library
Objectives In non‐small cell lung cancer (NSCLC), the immune system and possibly its
composition affect survival. In this in silico study, the immune infiltrate composition in NSCLC …

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance

A Chakravarthy, I Reddin, S Henderson, C Dong… - Nature …, 2022 - nature.com
Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer
deaths in women. Here we present an integrated multi-omic analysis of 643 cervical …

Benzo [a] pyrene immunogenetics and immune archetype reprogramming of lung

EE Abd El-Fattah, AM Abdelhamid - Toxicology, 2021 - Elsevier
Overexposure to carcinogenic precursor, benzo [a] pyrene [BaP], modulates the lung
immune microenvironment. The present review seeks to elucidate novel pathways behind …

Unique TP53 neoantigen and the immune microenvironment in long-term survivors of Hepatocellular carcinoma

H Yang, L Sun, A Guan, H Yin, M Liu, X Mao… - Cancer Immunology …, 2021 - Springer
Neoantigens are T-cell antigens derived from protein-coding mutations in tumor cells.
Although neoantigens have recently been linked to anti-tumor immunity in long-term …

Role of tumor-associated neutrophils in lung cancer

J Zhou, H Liu, S Jiang, W Wang - Oncology Letters, 2022 - spandidos-publications.com
Lung cancer is the most common malignancy and the leading cause of cancer mortality
worldwide; therefore, it is very important to understand the mechanism of its occurrence and …

The oncolytic bacteria-mediated delivery system of CCDC25 nucleic acid drug inhibits neutrophil extracellular traps induced tumor metastasis

L Liu, C Chen, W Xin, Q Li, C Han, Z Hua - Journal of Nanobiotechnology, 2024 - Springer
Abstract Background Neutrophil extracellular traps (NETs), antibacterial weapons of
neutrophils (NEs), have been found to play a crucial role in cancer metastasis in recent …

Informing the new developments and future of cancer immunotherapy: Future of cancer immunotherapy

A Kumar, CA Swain, LA Shevde - Cancer and Metastasis Reviews, 2021 - Springer
The application of cancer immunotherapy (CIT) in reinforcing anti-tumor immunity in
response to carcinogenesis and metastasis has shown promising advances, along with new …

Mass spectrometry imaging reveals neutrophil defensins as additional biomarkers for anti-PD-(L) 1 immunotherapy response in NSCLC patients

E Berghmans, J Jacobs, C Deben, C Hermans… - Cancers, 2020 - mdpi.com
(1) Background: Therapeutic blocking of the interaction between programmed death-1 (PD-
1) with its ligand PD-L1, an immune checkpoint, is a promising approach to restore the …