As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Cancer metastasis, ie, the spreading of tumor cells from the primary tumor to distant organs,
is responsible for the vast majority of cancer deaths. In the process, cancer cells migrate …

Bone tissue requires a range of complex mechanisms to allow the restoration of its structure
and function. Bone healing is a signaling cascade process, involving cells secreting …

Differentiation is the process by which a cell activates the expression of tissue-specific
genes, downregulates the expression of potency markers, and acquires the phenotypic …

To spread from a localized tumor, metastatic cancer cells must squeeze through
constrictions that cause major nuclear deformations. Since chromosome structure affects …

Cultivated meat production requires bioprocess optimization to achieve cell densities that
are multiple orders of magnitude higher compared to conventional cell culture techniques …

During metastasis, tumour cells navigating the vascular circulatory system—circulating
tumour cells (CTCs)—encounter capillary beds, where they start the process of …

Mutations in the genes LMNA and BANF1 can lead to accelerated aging syndromes called
progeria. The protein products of these genes, A-type lamins and BAF, respectively, are …

Cells adapt and move due to chemical, physical, and mechanical cues from their
microenvironment. It is therefore important to create materials that mimic human tissue …