Combined effect of shaking orbit and vial orientation on the agitation-induced aggregation of proteins
S Dasnoy, M Illartin, J Queffelec, A Nkunku… - Journal of …, 2024 - Elsevier
Orbital shaking in a glass vial is a commonly used forced degradation test to evaluate
protein propensity for agitation-induced aggregation. Vial shaking in horizontal orientation …
protein propensity for agitation-induced aggregation. Vial shaking in horizontal orientation …
An Underlying Cause and Solution to the Poor Size Exclusion Chromatography Performance of Antibody–Drug Conjugates
JZ Liu, CY Du, H Gao, H Wang, F Hu… - Pharmaceutical Research, 2024 - Springer
Methods Two kinds of ADCs with varying hydrophobicity properties and their corresponding
monoclonal antibodies are used as models. The hydrophobicity of these products was …
monoclonal antibodies are used as models. The hydrophobicity of these products was …
The Effects of Excipients on Freeze-dried Monoclonal Antibody Formulation Degradation and Sub-Visible Particle Formation during Shaking
MJ Jin, XZ Ge, Q Huang, JW Liu, RG Ingle… - Pharmaceutical …, 2024 - Springer
Purposes We previously reported an unexpected phenomenon that shaking stress could
cause more protein degradation in freeze-dried monoclonal antibody (mAb) formulations …
cause more protein degradation in freeze-dried monoclonal antibody (mAb) formulations …
[HTML][HTML] Don't shake it! Mechanical stress testing of mRNA-lipid nanoparticles
A Ruppl, D Kiesewetter, F Strütt, M Köll-Weber… - European Journal of …, 2024 - Elsevier
Shaking stress studies are typically performed during formulation development to test the
liability of a drug product towards interfacial stress occurring during transport, especially if a …
liability of a drug product towards interfacial stress occurring during transport, especially if a …
A Novel Size Exclusion Chromatography Method for the Analysis of Monoclonal Antibodies and Antibody–drug Conjugates by Using Sodium Iodide in the Mobile …
JZ Liu, L Li, WJ Fang - Pharmaceutical Research, 2024 - Springer
Purposes Size exclusion chromatography (SEC) is widely used to characterize molecular
size variants of antibody drugs. However, SEC analysis is hindered by secondary …
size variants of antibody drugs. However, SEC analysis is hindered by secondary …