Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Alcohol intake provokes severe organ injuries including alcoholic cardiomyopathy with
hallmarks of cardiac remodeling and contractile defects. This study examined the toxicity of …

Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …

Excessive ethanol exposure is detrimental to the brain. The developing brain is particularly
vulnerable to ethanol such that prenatal ethanol exposure causes fetal alcohol spectrum …

Alcohol abuse; the most common and costly form of drug abuse, is a major contributing
factor to many disease categories. The alcohol-attributable disease burden is closely related …

Background Mitochondrial aldehyde dehydrogenase (ALDH2) displays some promise in the
protection against cardiovascular diseases although its role in diabetes has not been …

Background Sepsis is a severe syndrome of organ dysfunction that often leads to cardiac
dysfunction and endangers life. The role of mitochondrial aldehyde dehydrogenase 2 …

Mitochondrial aldehyde dehydrogenase (ALDH2) protects against cardiac injury via
reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study was designed to …

hydroxy-2-nonenal (4-HNE), a reactive aldehyde, is generated from polyunsaturated fatty
acids (PUFAs) in biological membranes. Reactive oxygen species (ROS) generated during …