The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …

Background: A recent review by the International Agency for Research on Cancer (IARC)
updated the assessments of the> 100 agents classified as Group 1, carcinogenic to humans …

Thousands of chemicals have been profiled by high-throughput screening programs such as
ToxCast and Tox21; these chemicals are tested in part because most of them have limited or …

Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …

In vitro chemical safety testing methods offer the potential for efficient and economical tools
to provide relevant assessments of human health risk. To realize this potential, methods are …

Chemical toxicity can arise from disruption of specific biomolecular functions or through
more generalized cell stress and cytotoxicity-mediated processes. Here, responses of 1060 …

Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

We demonstrate a computational network model that integrates 18 in vitro, high-throughput
screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin …