The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …

Abstract Linear Energy Transfer (LET) is widely used to express the radiation quality of ion
beams, when characterizing the biological effectiveness. However, averaged LET may be …

The linear-quadratic model is one of the key tools in radiation biology and physics. It
provides a simple relationship between cell survival and delivered dose:, and has been …

While many efforts have been made to pave the way toward human space colonization, little
consideration has been given to the methods of protecting spacefarers against harsh cosmic …

Radiation-induced foci (RIF) are nuclear puncta visualized by immunostaining of proteins
that regulate DNA double-strand break (DSB) repair after exposure to ionizing radiation. RIF …

Robust predictive models are essential to manage the risk of radiation-induced
carcinogenesis. Chronic exposure to cosmic rays in the context of the complex deep space …

We present here an analysis of DSB induction and processing after irradiation with X-rays in
an extended dose range based on the use of the γH2AX assay. The study was performed by …

In cellular experiments, radiation-induced DNA damage can be quantified by counting the
number of γ-H2AX foci in cell nucleus by using an immunofluorescence microscope …

We present a comprehensive comparative analysis on the repair of radiation-induced DNA
damage ex vivo in 15 strains of mice, including 5 inbred reference strains and 10 …

We present a novel mathematical formalism to predict the kinetics of DNA damage repair
after exposure to both low-and high-LET radiation (X rays; 350 MeV/n 40Ar; 600 MeV/n …