Introduction Paracetamol is one of the most used medicines worldwide and is the most
common important poisoning in high-income countries. In overdose, paracetamol causes …

Acetaminophen is a commonly used analgesic and antipyretic agent and in recommended
therapeutic doses, is safe in healthy individuals. Because of wide availability and minimal …

Context: Paracetamol (acetaminophen) poisoning is the most common cause of acute liver
failure in the developed world. A paracetamol treatment nomogram has been used for over …

Paracetamol poisoning was first reported in 1966. The development of antidotes followed
within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal …

Introduction Acetaminophen (N-acetyl-para-aminophenol or APAP) is the leading cause of
acute liver failure worldwide. Standard therapy for APAP overdose is with IV N …

Background & Aims Acetaminophen-protein adducts are specific biomarkers of toxic
acetaminophen (paracetamol) metabolite exposure. In patients with hepatotoxicity (alanine …

Introduction Acetaminophen (paracetamol) is a commonly used analgesic and antipyretic
agent, which is safe in therapeutic doses. Acetaminophen poisoning due to self-harm or …

Fomepizole should be used more liberally in paracetamol overdose - Filip - 2023 - British Journal of
Clinical Pharmacology - Wiley Online Library Skip to Article Content Skip to Article Information …

Introduction Acetaminophen (paracetamol, APAP) poisoning is a prominent global cause of
drug-induced liver injury. While N-acetylcysteine (NAC) is an effective antidote, it has …

Introduction Fomepizole inhibits formation of toxic acetaminophen (APAP) metabolites and
may prevent or reverse mitochondrial toxicity. Given these mechanisms, it may be beneficial …