Protein complexes form a basis for complex hybrid incompatibility

KBS Swamy, SC Schuyler, JY Leu - Frontiers in genetics, 2021 - frontiersin.org
Proteins are the workhorses of the cell and execute many of their functions by interacting
with other proteins forming protein complexes. Multi-protein complexes are an admixture of …

Assessment of a large-scale unbiased malignant pleural effusion proteomics study of a real-life cohort

S Zahedi, AS Carvalho, M Ejtehadifar, HC Beck, N Rei… - Cancers, 2022 - mdpi.com
Simple Summary Pleural effusion (PE) occurs as a consequence of various pathologies.
Malignant effusion due to lung cancer is one of the most frequent causes. A method for …

DM-MOGA: a multi-objective optimization genetic algorithm for identifying disease modules of non-small cell lung cancer

J Shang, X Zhu, Y Sun, F Li, X Kong, JX Liu - BMC bioinformatics, 2023 - Springer
Background Constructing molecular interaction networks from microarray data and then
identifying disease module biomarkers can provide insight into the underlying pathogenic …

Knowledge-guided “Community Network” analysis reveals the functional modules and candidate targets in non-small-cell lung cancer

F Wang, S Han, J Yang, W Yan, G Hu - Cells, 2021 - mdpi.com
Non-small-cell lung cancer (NSCLC) represents a heterogeneous group of malignancies
that are the leading cause of cancer-related death worldwide. Although many NSCLC …

The doxorubicin‐induced cell motility network is under the control of the ceramide‐activated protein phosphatase 1 alpha

D Canals, S Salamone, BJ Santacreu… - The FASEB …, 2021 - Wiley Online Library
We have recently reported that a specific pool of ceramide, located in the plasma
membrane, mediated the effects of sublethal doses of the chemotherapeutic compound …

SciGeneX: Enhancing transcriptional analysis through gene module detection in single-cell and spatial transcriptomics data.

J Bavais, J Chevallier, L Spinelli, S van de Pavert… - bioRxiv, 2024 - biorxiv.org
The standard pipeline to analyze scRNA-seq or spatial transcriptomics data focuses on a
gene-centric approach, which overlooks the collective behavior of genes. However, cell …

A heterogeneous parallel implementation of the Markov clustering algorithm for large-scale biological networks on distributed CPU–GPU clusters

Y Fu, W Zhou - The Journal of Supercomputing, 2022 - Springer
Biological interaction databases accommodate information about interacted proteins or
genes. Clustering on the networks formed by the interaction information for finding regions …

[PDF][PDF] Knowledge-Guided Community Network” Analysis Reveals the Functional Modules and Candidate Targets in Non-Small-Cell Lung Cancer. Cells 2021, 10, 402

F Wang, S Han, J Yang, W Yan, G Hu - 2021 - pdfs.semanticscholar.org
Non-small-cell lung cancer (NSCLC) represents a heterogeneous group of malignancies
that are the leading cause of cancer-related death worldwide. Although many NSCLC …

Hub Genes Identification in Brain Cancer with Gene Expression Data

SPBM Senadheera… - 2020 20th International …, 2020 - ieeexplore.ieee.org
Central nervous system (CNS) cancers are one of the leading cancer types in the world.
Analysing gene hubs involved in CNS cancer is important for predicting therapies. We have …

A Novel Epitope Dataset: Performance of the MCL-Based Algorithms to Generate Dataset for Graph Learning Model

B Solihah, A Musdholifah, A Azhari - Engineering Innovations, 2023 - Trans Tech Publ
Naturally, the epitope dataset can be presented as a graph. Dataset preparation in the
previous methods is part of model development. There are many graph-based classification …