DNA repair pathways in cancer therapy and resistance
L Li, Y Guan, X Chen, J Yang, Y Cheng - Frontiers in pharmacology, 2021 - frontiersin.org
DNA repair pathways are triggered to maintain genetic stability and integrity when
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …
Targeting ATR in cancer
E Lecona, O Fernandez-Capetillo - Nature Reviews Cancer, 2018 - nature.com
The chemical treatment of cancer started with the realization that DNA damaging agents
such as mustard gas present notable antitumoural properties. Consequently, early drug …
such as mustard gas present notable antitumoural properties. Consequently, early drug …
ATM in DNA repair in cancer
MH Jin, DY Oh - Pharmacology & therapeutics, 2019 - Elsevier
Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
ST Durant, L Zheng, Y Wang, K Chen, L Zhang… - Science …, 2018 - science.org
Poor survival rates of patients with tumors arising from or disseminating into the brain are
attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier …
attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier …
Targeting the ATR-CHK1 axis in cancer therapy
S Rundle, A Bradbury, Y Drew, NJ Curtin - Cancers, 2017 - mdpi.com
Targeting the DNA damage response (DDR) is a new therapeutic approach in cancer that
shows great promise for tumour selectivity. Key components of the DDR are the ataxia …
shows great promise for tumour selectivity. Key components of the DDR are the ataxia …
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
N Bonagas, NMS Gustafsson, M Henriksson, P Marttila… - Nature cancer, 2022 - nature.com
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/
cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully …
cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully …
Resistance to DNA repair inhibitors in cancer
The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …
Targeting the replication stress response in cancer
JV Forment, MJ O'Connor - Pharmacology & therapeutics, 2018 - Elsevier
Many conventional chemotherapies used in cancer treatment exert their effect by inflicting
DNA damage. Highly proliferative tissues, as well as tumour cells, are particularly vulnerable …
DNA damage. Highly proliferative tissues, as well as tumour cells, are particularly vulnerable …
Exploring the links between cancer and placenta development
V Costanzo, A Bardelli, S Siena… - Open …, 2018 - royalsocietypublishing.org
The development of metastatic cancer is a multistage process, which often requires decades
to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors …
to complete. Impairments in DNA damage control and DNA repair in cancer cell precursors …
A consensus set of genetic vulnerabilities to ATR inhibition
N Hustedt, A Álvarez-Quilón, A McEwan… - Open …, 2019 - royalsocietypublishing.org
The response to DNA replication stress in eukaryotes is under the control of the ataxia–
telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to …
telangiectasia and Rad3-related (ATR) kinase. ATR responds to single-stranded (ss) DNA to …