Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

Angiogenesis is the formation of new capillaries from pre-existing vasculature, which plays a
critical role in the pathogenesis of several inflammatory autoimmune diseases such as …

Imbalance between the activities of pro-inflammatory M1 and anti-inflammatory M2
macrophages in rheumatoid arthritis (RA) induces synovial inflammation and autoimmunity …

Macrophages display remarkable plasticity and can change their physiology in response to
environmental cues. These changes can give rise to different populations of cells with …

Acute inflammation is a recognised part of normal wound healing. However, when
inflammation fails to resolve and a chronic inflammatory response is established this …

Tumor-associated myeloid cells have been implicated in regulating many of the “hallmarks
of cancer” and thus fostering solid tumor development and metastasis. However, the same …

Monocytes and macrophages are innate immune cells that reside and accumulate in the
healthy and injured heart. The cells and their subsets pursue distinct functions in steady …

Fucosylation is a biological process broadly observed in vertebrates, invertebrates, plants,
bacteria, and fungi. Fucose moieties on cell-surface glycans are increasingly recognized as …

Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

Although glucocorticoids are the mainstays in the treatment of renal diseases for decades,
the dose dependent side effects have largely restricted their clinical use. Microvesicles …