Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …

CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

Brain tumors, especially glioblastoma, remain the most aggressive form of all the cancers
because of inefficient diagnosis and profiling. Nanostructures, such as metallic …

Nanotechnology has been applied in the medicine field to improve the treatment of a wide
range of diseases. However, to reach the nanomedicines delivery to desirable target tissue …

It has been seventy years since a water-soluble version of vitamin E called tocophersolan
(also known as TPGS) was produced; it was approved by USFDA in 1998 as an inactive …

Abstract Treatment of glioblastoma multiforme (GBM) is a predominant challenge in
chemotherapy due to the existence of blood–brain barrier (BBB) which restricts delivery of …

In recent years, nanomedicines have emerged as a promising method for central nervous
system drug delivery, enabling the drugs to overcome the blood-brain barrier and …

Background The safe and efficient delivery of chemotherapeutic agents is critical to glioma
therapy. However, chemotherapy for glioma is extremely challenging because the blood …

Nanotheranostics have demonstrated the development of advanced platforms that can
diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed …