Kinin B1 receptors as a therapeutic target for inflammation

F Qadri, M Bader - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Estradiol alters hippocampal gene expression during the estrous cycle

J Iqbal, ZN Tan, MX Li, HB Chen, B Ma, X Zhou… - Endocrine …, 2020 - Taylor & Francis
Estrogen (E2) modulates a wide range of neural functions such as spine formation, synaptic
plasticity, and neurotransmission in the hippocampus. Dendritic spines and synapse …

Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats

RM Bitencourt, ACG de Souza, MA Bicca… - Behavioural Brain …, 2017 - Elsevier
Previous studies have demonstrated that targeting bradykinin receptors is a promising
strategy to counteract the cognitive impairment related with aging and Alzheimer's disease …

Kinin B2 receptor activation prevents the evolution of Alzheimer's Disease pathological characteristics in a transgenic mouse model

MA Nunes, M Toricelli, NM Schöwe, HN Malerba… - Pharmaceuticals, 2020 - mdpi.com
Background: Alzheimer's disease is mainly characterized by remarkable neurodegeneration
in brain areas related to memory formation. This progressive neurodegeneration causes …

The expression of bradykinin and its receptors in spinal cord ischemia-reperfusion injury rat model

Z Ma, Q Dong, B Lyu, J Wang, Y Quan, S Gong - Life sciences, 2019 - Elsevier
Objective To investigate the expression and time-dependent manner of bradykinin (BK) as
well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia …

[PDF][PDF] Bradykinin-an undervalued mediator

K Belowska-Bień, E Szeląg, J Szeląg… - Post N Med, 2017 - pnmedycznych.pl
The paper aims to analyse basic mechanisms of pathological processes in various tissues
and organs that apparently are not related but may be associated with bradykinin, a poorly …

Neuroprotective effects of kinin B2 receptor in organotypic hippocampal cultures of middle-aged mice

M Toricelli, SR Evangelista, LR Oliveira… - Frontiers in Aging …, 2019 - frontiersin.org
Aging is a multifactorial phenomenon that results in several changes at cellular and
molecular levels and is considered the main risk factor for some neurodegenerative …

[PDF][PDF] Effect of bradykinin receptor 1 and acid-sensing ion channel 1a on outcome after experimental traumatic brain injury

S Cheng - 2020 - edoc.ub.uni-muenchen.de
Traumatic brain injury (TBI) is a cerebral insult with high morbidity and mortality. In past
decades, TBI imposed a heavy socioeconomic burden on society, leading to relevant public …

[HTML][HTML] Bradykinina–niedoceniany mediator?

K Belowska-Bień, E Szeląg, J Szeląg… - Postępy Nauk …, 2017 - czytelniamedyczna.pl
Celem pracy jest przeanalizowanie podstawowych mechanizmów procesów patologicznych
w różnych tkankach i narządach, które pozornie nie mają ze sobą związku, a mogą być …

[引用][C] 血清缓激肽水平与阿尔茨海默病及遗忘型轻度认知障碍的临床研究

李甜甜, 王海峰, 王新, 庄珊, 邢成名 - 中国医刊, 2016