Metabolism and detoxification of pesticides in plants

JJ Zhang, H Yang - Science of the Total Environment, 2021 - Elsevier
Pesticides make indispensable contributions to agricultural productivity. However, the
residues after their excessive use may be harmful to crop production, food safety and human …

Removal of chlorimuron-ethyl from the environment: The significance of microbial degradation and its molecular mechanism

H Song, WJ Chen, SF Chen, X Zhu, S Mishra… - Chemosphere, 2024 - Elsevier
Chlorimuron-ethyl is a selective pre-and post-emergence herbicide, which is widely used to
control broad-leaved weeds in soybean fields. However, herbicide residues have also …

CYP81A P450s are involved in concomitant cross‐resistance to acetolactate synthase and acetyl‐CoA carboxylase herbicides in Echinochloa phyllopogon

S Iwakami, Y Kamidate, T Yamaguchi… - New …, 2019 - Wiley Online Library
Californian populations of Echinochloa phyllopogon have evolved multiple‐herbicide
resistance (MHR), posing a threat to rice production in California. Previously, we identified …

Functional characterization of cytochrome P450 CYP81A subfamily to disclose the pattern of cross-resistance in Echinochloa phyllopogon

NG Dimaano, T Yamaguchi, K Fukunishi… - Plant Molecular …, 2020 - Springer
Metabolism-based herbicide resistance is a major threat to agriculture, as it is unpredictable
and could extend resistance to different chemical groups and modes of action …

Chemical Synthesis, Herbicidal Activity, Crop Safety, and Molecular Basis of ortho-Fluoroalkoxy Substituted Sulfonylureas as Novel Acetohydroxyacid Synthase …

Q Xu, Y Gao, Z Sun, JR Shi, JY Tang… - Journal of Agricultural …, 2024 - ACS Publications
In the face of increasing resistance to the currently used commercial herbicides and the lack
of success in identifying new herbicide targets, alternative herbicides need to be developed …

Synthetic biology for pharmaceutical drug discovery

JY Trosset, P Carbonell - Drug design, development and therapy, 2015 - Taylor & Francis
Synthetic biology (SB) is an emerging discipline, which is slowly reorienting the field of drug
discovery. For thousands of years, living organisms such as plants were the major source of …

Human cytochrome P450 1, 2, 3 families as pharmacogenes with emphases on their antimalarial and antituberculosis drugs and prevalent African alleles

CR Chamboko, W Veldman, RB Tata… - International Journal of …, 2023 - mdpi.com
Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …

Cytochrome P450 CYP90D5 enhances degradation of the herbicides isoproturon and acetochlor in rice plants and grains

XN Su, XS Liu, CY Li, YP Zhang - Journal of Agricultural and Food …, 2023 - ACS Publications
The rice cytochrome P450 gene has been comprehensively studied in the present study.
This gene encodes CYP90D5 in promoting the degradation of isoproturon (IPU) and …

Characterization of cytochrome P450s with key roles in determining herbicide selectivity in maize

M Brazier-Hicks, S Franco-Ortega, P Watson… - ACS …, 2022 - ACS Publications
Safeners such as metcamifen and benoxacor are widely used in maize to enhance the
selectivity of herbicides through the induction of key detoxifying enzymes, notably …

An ABCG-type transporter intensifies ametryn catabolism by Phase III reaction mechanism in rice

Y Qiao, AIP Zhang, LY Ma, N Zhang, J Liu… - Journal of Hazardous …, 2023 - Elsevier
Pesticide residues in food crops are one of the seriously environmental contaminants that
risk food safety and human health. Understanding the mechanism for pesticide catabolism is …