Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …

Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis
remains incompletely understood. Here, we profile 174,962 single cells from the foot …

Wound healing is a complicated physiological process that comprises various steps,
including hemostasis, inflammation, proliferation, and remodeling. The wound healing …

The human amniotic membrane (HAM) collagen matrix derived from human placenta can be
decellularized (dHAM) to form a natural biocompatible material. dHAM has different …

Objective. Type 2 diabetes mellitus (T2DM) is featured by insulin resistance and lipid
metabolism dysregulation. A large number of miRNAs were identified in exosomes derived …

Chronic wounds fail to achieve complete closure and are an economic burden to healthcare
systems due to the limited treatment options and constant medical attention. Chronic …

Significance: microRNA-210 (miR-210) is the master hypoxia-inducible miRNA (hypoxamiR)
since it has been found to be significantly upregulated under hypoxia in a wide range of cell …

Background Delayed wound healing in skin injuries has become a significant problem in
clinics, seriously affecting and even threatening life and health. Recently, research interest …

Dysregulation of sequential and synchronized events of skin regeneration often results in
the impairment of chronic wounds. Conventional wound dressings fail to trigger the normal …

Impaired wound healing in people with diabetes has multifactorial causes, with insufficient
neovascularization being one of the most important. Hypoxia-inducible factor-1 (HIF-1) plays …