Results: It seems that persistent antigenic stimulation and oxidative stress from excessive
iron are the two main pathophysiologic factors of TM impacting the immune system …

Background: β-thalassemia major is a common hereditary blood disease that can affect
patients' oral health and quality of life. The present study aims to determine the relationship …

Beta-thalassemia is one of the most common monogenic inherited disorders worldwide
caused by different mutations in the hemoglobin subunit beta (HBB) gene. Genome-editing …

Objectives In the present study, we assessed the frequency of HT and HPT in a population of
TM patients in Southeast of Iran. Methods This cross sectional study was performed on 194 …

Abstract β-Thalassemia (β-thal) is one of the most common hemoglobinopathies worldwide
and is caused by mutations on the β-globin (HBB) gene. The aim of the present study was to …

BACKGROUND: β-thalassemias are widely distributed in Mediterranean and Middle Eastern
countries, including Iraq. There are more than 400 transfusion-dependent β-thalassemia …

Background: Cholelithiasis and its predisposing factors are less characterized in
thalassemia syndromes. In the present study, we assessed the prevalence of gallstones and …

Background It is difficult to classify a small fraction of α-and β-thalassemia (α-and β-thal)
carriers based on their Hb A2 levels. Here, we report the results of a molecular investigation …

Abstract Background 6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency is an
autosomal recessive disorder caused by PTS gene mutations. The aim of this study was to …

Background: Thalassemia is the most common hereditary anemia which has a relatively
high prevalence in Iran. In most cases, more than 300 mutations have been identified, which …