This review briefly summarizes the actions of melatonin in reducing molecular damage
caused by free radicals and associated oxygen-and nitrogenbased reactants. All the …

Melatonin, one of the evolutionarily most ancient, highly conserved and most pleiotropic
hormones still operative in man, couples complex tissue functions to defined changes in the …

The toxicity of gentamicin (GEN) in the kidney seems to relate to the generation of reactive
oxygen species (ROS). Caffeic acid phenethyl ester (CAPE) has been demonstrated to have …

Oxidative stress is considered to be the main cause of diabetic complications. As the role of
antioxidants in diabetes therapy is still underestimated, the aim of the present investigation …

The aims of this study were to examine vancomycin (VCM)-induced oxidative stress that
promotes production of reactive oxygen species (ROS) and to investigate the role of …

Colistin-induced nephrotoxicity is a dose-limiting adverse effect when colistin is used
against Gram-negative pathogens. This study examined the nephroprotective effect of …

The toxicity of aminoglycosides including gentamicin (GEN), the most widely used drug in
this category, is believed to be related to the generation of reactive oxygen species (ROS) in …

The ameliorative role of curcumin in attenuating gentamicin-induced nephrotoxicity has
been reported earlier however, the mechanism of action remains unclear. Gentamicin was …

Amikacin (AK) has the largest spectrum of aminoglycosides. However, its use is constrained
because of nephrotoxicity and ototoxicity. Ellagic acid (EA) is a polyphenol present in plants …

Background: Ischemia-reperfusion (I/R) injury is a leading cause of surgical skin flap
compromise and organ dysfunction. Platelet-rich plasma (PRP) is an abundant reserve of …