Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An ORS …
IP Melgoza, SS Chenna, S Tessier, Y Zhang… - JOR …, 2021 - Wiley Online Library
Mice have been increasingly used as preclinical model to elucidate mechanisms and test
therapeutics for treating intervertebral disc degeneration (IDD). Several intervertebral disc …
therapeutics for treating intervertebral disc degeneration (IDD). Several intervertebral disc …
Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB …
F Li, X Sun, B Zheng, K Sun, J Zhu, C Ji… - Frontiers in Cell and …, 2021 - frontiersin.org
Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of
low back pain (LBP), which imposes massive clinical and socioeconomic burdens. Previous …
low back pain (LBP), which imposes massive clinical and socioeconomic burdens. Previous …
[HTML][HTML] Transcription regulators differentiate mesenchymal stem cells into chondroprogenitors, and their in vivo implantation regenerated the intervertebral disc …
S Khalid, S Ekram, A Salim… - World Journal of Stem …, 2022 - ncbi.nlm.nih.gov
BACKGROUND Intervertebral disc degeneration (IVDD) is the leading cause of lower back
pain. Disc degeneration is characterized by reduced cellularity and decreased production of …
pain. Disc degeneration is characterized by reduced cellularity and decreased production of …
Sod2 and catalase improve pathological conditions of intervertebral disc degeneration by modifying human adipose-derived mesenchymal stem cells
L Xiao, SJ Xu, C Liu, J Wang, B Hu, HG Xu - Life Sciences, 2021 - Elsevier
Objective To investigate if the modification of human adipose-derived mesenchymal stem
cells (hADSCs) by the antioxidants superoxide dismutase 2 (Sod2) and catalase (Cat) can …
cells (hADSCs) by the antioxidants superoxide dismutase 2 (Sod2) and catalase (Cat) can …
Pralatrexate sustainably released from polypeptide thermogel is effective for chondrogenic differentiation of mesenchymal stem cells
Y Woo, M Patel, H Kim, JK Park, YJ Jung… - … Applied Materials & …, 2022 - ACS Publications
Folic acid was reported to significantly improve chondrogenic differentiation of mesenchymal
stem cells. In a similar mechanism of action, we investigated clinically approved antifolates …
stem cells. In a similar mechanism of action, we investigated clinically approved antifolates …
Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair
D Zujur, Z Al-Akashi, A Nakamura, C Zhao… - Frontiers in Cell and …, 2023 - frontiersin.org
Background: To date, there is no effective long-lasting treatment for cartilage tissue repair.
Primary chondrocytes and mesenchymal stem/stromal cells are the most commonly used …
Primary chondrocytes and mesenchymal stem/stromal cells are the most commonly used …
[HTML][HTML] Engineered extracellular vesicle-based gene therapy for the treatment of discogenic back pain
SN Tang, AI Salazar-Puerta, MK Heimann… - Biomaterials, 2024 - Elsevier
Painful musculoskeletal disorders such as intervertebral disc (IVD) degeneration associated
with chronic low back pain (termed “Discogenic back pain”, DBP), are a significant socio …
with chronic low back pain (termed “Discogenic back pain”, DBP), are a significant socio …
小分子药物TD-198946 促进大鼠骨髓间充质干细胞的成骨分化
杨超， 罗宗平 - 中国组织工程研究, 2025 - cjter.com
小分子药物TD-198946 促进大鼠骨髓间充质干细胞的成骨分化 Page 1 2648|中国组织工程
研究|第29卷|第13期|2025年5月 中国组织工程研究 Chinese Journal of Tissue Engineering …
研究|第29卷|第13期|2025年5月 中国组织工程研究 Chinese Journal of Tissue Engineering …