Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a
state of out-of-control release of a variety of inflammatory cytokines. The molecular …

Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some
patients, lung infection leads to the activation of alveolar macrophages and lung epithelial …

Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase with important
functions in the renin-angiotensin system and plays a critical role in inflammatory lung …

Situated between the circulation and the brain, the blood–brain barrier (BBB) protects the
brain from circulating toxins while securing a specialized environment for neuro-glial …

Aims Neurovascular-glymphatic dysfunction plays an important role in Alzheimer's disease
and has been analysed mainly in relation to amyloid-beta (Aβ) pathology. Here, we aim to …

Telomeres, at the ends of chromosomes and strands of genetic material, become shorter as
cells divide in the process of aging. Telomere length has been considered as a biological …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Vascular abnormalities and inflammation are found in many Alzheimer disease (AD)
patients, but whether these changes play a causative role in AD is not clear. The factor XII …

Acute ischemic stroke and traumatic brain injury are a major cause of mortality and
morbidity. Due to the paucity of therapies, there is a pressing clinical demand for new …

Alzheimer's disease (AD) is characterized by the presence of proteinaceous brain deposits,
brain atrophy, vascular dysfunction, and chronic inflammation. Along with cerebral …