Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

Objective Mechanical stimulation regulates many cell responses. The present study
describes the effects of different in vitro mechanical stimulation approaches on stem cell …

Regenerative medicine is recognized as one of the developing sciences in the world. Repair
of bone injuries using stem cells and biomaterials has been considered by reconstructive …

Human periodontal ligament stem cells (hPDLSCs) can undergo osteogenic differentiation
under induction conditions. Cyclic tensile stress (CTS) can stimulate stem cell osteogenic …

Background Trans-sutural distraction osteogenesis (TSDO) involves the application of
distraction force to facial sutures to stimulate osteogenesis. Gli1+ cells in the cranial sutures …

Introduction Mechanical stimulation has been proven to promote bone-tendon interface (BTI)
healing, but the mechanism remains unclear. Objective To investigate the effects of …

At the core of regenerative medicine lies the expectation of repair or replacement of
damaged tissues or whole organs. Donor scarcity and transplant rejection are major …

Hyperlipidemia adversely affects bone metabolism, often resulting in compromised
osseointegration and implant loss. In addition, genetic networks associated with …

Bone marrow mesenchymal stem cells (BM-MSCs) are self-renewing cells with
multidirectional differentiation potential. As the origin of osteogenic cell lineage, BM-MSCs …

Human adipose-derived stem cells (hASCs) have multi-directional differentiation potential
including osteogenic differentiation. Mechanical stimulation is thought to be a key regulator …