The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Tauopathies are age-related neurodegenerative diseases that are characterized by the
presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered …

Significant attention has recently been drawn to the potential link between head trauma and
the development of neurodegenerative disease, namely chronic traumatic encephalopathy …

The ubiquitous eukaryotic 14‐3‐3 proteins coordinate multiple cellular processes due to
their well‐known regulatory function, which is based on specific recognition of …

Alpha-synuclein (α-syn) is a small protein that, in neurons, localizes predominantly to
presynaptic terminals. Due to elevated conformational plasticity, which can be affected by …

Among the first reported functions of 14-3-3 proteins was the regulation of tyrosine
hydroxylase (TH) activity suggesting a possible involvement of 14-3-3 proteins in …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of
inherited Parkinson's disease (PD), and LRRK2 is a risk factor for idiopathic PD. How …

One of the most abundant proteins expressed in the brain, 14-3-3 comprises about 1% of the
brain's total soluble proteins. The 14-3-3 isoforms bind to specific phosphoserine-and …

Alzheimer's disease (AD) is characterized by the presence of abnormal, straight filaments
and paired helical filaments (PHFs) that are coated with amorphous aggregates. When …

Abstract The proteins of the 14-3-3 family are universal adapters participating in multiple
processes running in the cell. We describe the structure, isoform composition, and …