The Usnic Acid Analogue 4-FPBUA Enhances the Blood–Brain Barrier Function and Induces Autophagy in Alzheimer's Disease Mouse Models
SB Al Rihani, KH Elfakhri, HY Ebrahim… - ACS Chemical …, 2024 - ACS Publications
Preclinical and clinical studies have indicated that compromised blood–brain barrier (BBB)
function contributes to Alzheimer's disease (AD) pathology. BBB breakdown ranged from …
function contributes to Alzheimer's disease (AD) pathology. BBB breakdown ranged from …
[HTML][HTML] Lysosomal proteomics reveals mechanisms of neuronal apoE4associated lysosomal dysfunction
ApoE4 is the primary risk factor for Alzheimer's Disease. While apoE is primarily expressed
by astrocytes, AD pathology including endosomal abnormalities and mitochondrial …
by astrocytes, AD pathology including endosomal abnormalities and mitochondrial …
Impact of Suramin on Key Pathological Features of Sporadic Alzheimer's Disease-Derived Forebrain Neurons
Background: Alzheimer's disease (AD) is characterized by disrupted proteostasis and
macroautophagy (hereafter “autophagy”). The pharmacological agent suramin has known …
macroautophagy (hereafter “autophagy”). The pharmacological agent suramin has known …
Membrane Interactions in Alzheimers Treatment Strategies with Multitarget Molecules
P Zambrano - arXiv preprint arXiv:2403.06331, 2024 - arxiv.org
Addressing Alzheimer's disease (AD) requires innovative strategies beyond current single-
target drugs. This Letter to the Editor suggests that multitarget molecules, especially those …
target drugs. This Letter to the Editor suggests that multitarget molecules, especially those …
[引用][C] Membrane interactions in Alzheimer's disease treatment strategies with multitarget molecules.
P Zambrano - Bioorganic Chemistry, 2024 - europepmc.org
Membrane interactions in Alzheimer's disease treatment strategies with multitarget molecules.
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- Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe PMC Menu About …