Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

Inhibition of protein–protein interactions (PPIs) represents a significant challenge because it
is unclear how they can be effectively and selectively targeted using small molecules …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

The past several decades have witnessed great progress in the understanding of the high-
order structure of biomacromolecules. Currently, it is well-recognized that folding of proteins …

Foldamers are artificial folded molecular architectures inspired by the structures and
functions of biopolymers. This highlight focuses on important developments concerning …

Structure-based design of synthetic inhibitors of protein–protein interactions (PPIs) requires
adept molecular design and synthesis strategies as well as knowledge of targetable …

Over the past decade, foldamers have progressively emerged as useful architectures to
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …

Protein–protein interactions (PPIs) intimately govern various biological processes and
disease states and therefore have been identified as attractive therapeutic targets for small …

Many biological processes are regulated by protein–protein interactions (PPIs) and as such
their misregulation can cause a multitude of diseases. Often the interactions between large …

The growth of advanced prostate cancer depends on androgen receptor signalling, however
treatment options are limited. Here we report the disruption of specific protein–protein …