The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

The sympathetic nervous system provides the most powerful stimulation of cardiac function,
brought about via norepinephrine and epinephrine and their postsynaptic β-adrenergic …

Background Despite the accumulating genetic and molecular investigations into
hypertrophic cardiomyopathy (HCM), it remains unclear how this condition develops and …

Local signaling domains and numerous interacting molecular pathways and substrates
contribute to the whole-cell response of myocytes during β-adrenergic stimulation (βARS) …

Abstract β-Adrenergic receptors (βARs) belong to a large family of cell surface receptors
known as G protein–coupled receptors (GPCRs). They are coupled to Gs protein (Gαs) for …

An altered cardiac myofilament response to activating Ca 2+ is a hallmark of human heart
failure. Phosphorylation of cardiac troponin I (cTnI) is critical in modulating contractility and …

Heart failure occurs when the heart is unable to effectively pump blood and maintain tissue
perfusion. Despite numerous therapeutic advancements over previous decades, the …

Nitric oxide (NO) regulates cardiovascular hemostasis by binding to soluble guanylyl
cyclase (sGC), leading to cGMP production, reduced cytosolic calcium concentration ([Ca2+] …

The L-α-lysophosphatidylinositol (LPI)-sensitive receptor GPR55 is coupled to Ca 2+
signaling. Low levels of GPR55 expression in the heart have been reported. Similar to other …

Regulator of G protein signaling (RGS) proteins have emerged as novel drug targets since
their discovery almost two decades ago. RGS2 has received particular interest in …